I and you is a play that tells a few stories at once. Some of these will not (and need not) be garnered from watching or reading the play once, but I wanted to offer them up for post-show discussion.
The entire play takes place while Caroline is under anesthesia during her transplant surgery. In the realest reality of Caroline's life, the events of I and You are a kind of dream that she experiences while in surgery, a dream that she and Anthony are sharing. this does not mean that the play is a lie, that Anthony isn't really present, or that their encounter is not real.
Carolines's room is a metaphor for her body. After several drafts I realized that the room which cradles our story is a metaphor for the body that, in the play's final reveal, Anthony and Caroline are fated to share. If that is true, then Anthony's first entrance is the biological "entrance" His Flesh to hers in the operating room. When she distrust and rejects him in the first scene it is a metaphor for her body initially rejecting his organ. When he starts to give up on her and wants to leave her room later in the play it is his liver resisting her body's biology. When they hold hands, kiss and embrace at the end of the play, and they become isolated from the room, the metaphor would encourage us to see it as the anatomical harmony of a successful transplant. As Anthony, quoting Whitman, says in his last words to her: "shall be good health to you nevertheless, and filter and fibre your blood," which is exactly what a liver does.
American Theatre July/August 2014